Additional file 1 of Hierarchical functional nanoparticles boost osteoarthritis therapy by utilizing joint-resident mesenchymal stem cells

Additional file 1: Fig. S1. Cartilage-targeting effect of the control LPV-CuO NPs (red fluorescence). Scale bar = 100 ��m. Fig. S2. Flow cytometry analysis of SMSCs co-cultured with WPV-CuO, WGV-CuO, and PBS in the presence of MMP-2. Fig. S3. Cell viability of SMSCs co-cultured with CuO NPs after 24 h. Fig. S4. Chondrogenic inductivity of bare CuO NPs (n=3). Fig. S5. Micro-CT scan of the joints of OA rats treated with WPV-CuO or PBS (n=6). Fig. S6. H&E staining of the main organs of ACLT rats after different treatments.Scale bar = 500 ��m. Fig. S7. Biodistribution of the Cy5.5-labeled WPV-CuO NPs after intraarticular injection. Table S1. Peptide properties. Table S2. Primers sequence used for RT-qPCR.