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Roles and Regulation of Stat Family Transcription Factors in Human Breast Cancer
- Source :
- The American Journal of Pathology. 165:1449-1460
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Stats (for signal transducers and activators of transcription) are a family of transcription factors that regulate cell growth and differentiation. Their activity is latent until phosphorylation by receptor-associated kinases. A sizable body of data from cell lines, mouse models, and human tissues now implicates these transcription factors in the oncogenesis of breast cancer. Because Stat activity is modulated by several posttranslational modifications and protein-protein interactions, these transcription factors are capable of integrating inputs from multiple signaling networks. Given this, the future utilization of Stats as prognostic markers and therapeutic targets in human breast cancer appears likely.
- Subjects :
- STAT3 Transcription Factor
Amino Acid Motifs
Breast Neoplasms
Review
Biology
medicine.disease_cause
Models, Biological
stat
Pathology and Forensic Medicine
Mice
Structure-Activity Relationship
Transcription (biology)
STAT5 Transcription Factor
medicine
Animals
Humans
Protein inhibitor of activated STAT
Phosphorylation
Mammary Glands, Human
Transcription factor
STAT6
Genetics
ETS transcription factor family
Cancer
Milk Proteins
Prognosis
medicine.disease
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
STAT1 Transcription Factor
Trans-Activators
Cancer research
Tyrosine
Carcinogenesis
Subjects
Details
- ISSN :
- 00029440
- Volume :
- 165
- Database :
- OpenAIRE
- Journal :
- The American Journal of Pathology
- Accession number :
- edsair.doi.dedup.....888c1d2d61194115fdf973c395f00d48