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No evidence that genetic predictors of susceptibility predict changes in core outcomes in JIA
- Source :
- Childhood Arthritis Prospective Study (CAPS) Group 2022, ' No evidence that genetic predictors of susceptibility predict changes in core outcomes in JIA ', Rheumatology (Oxford, England) . https://doi.org/10.1093/rheumatology/keab942
- Publication Year :
- 2022
-
Abstract
- Objectives. The clinical progression of JIA is unpredictable. Knowing who will develop severe disease could facilitate rapid intensification of therapies. We use genetic variants conferring susceptibility to JIA to predict disease outcome measures. Methods. A total of 713 JIA patients with genotype data and core outcome variables (COVs) at diagnosis (baseline) and 1 year follow-up were identified from the Childhood Arthritis Prospective Study (CAPS). A weighted genetic risk score (GRS) was generated, including all single nucleotide polymorphisms (SNPs) previously associated with JIA susceptibility (P-value<br />Versus Arthritis 20542 22084 20621<br />Centre for Epidemiology Versus Arthritis (UK) 21755<br />National Institute for Health Research (NIHR)<br />Manchester Academic Health Sciences Centre (MAHSC)<br />CLUSTER consortium<br />UK Research & Innovation (UKRI)<br />Medical Research Council UK (MRC) MR/R013926/1<br />Great Ormond Street Hospital Children's Charity VS0518<br />Olivia's Vision<br />NIHR GOSH BRC<br />'UK's Experimental Arthritis Treatment Centre for Children by Versus Arthritis 20621<br />NIHR GOSH Biomedical Research Centre<br />British Society for Rheumatology (BSR)
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Childhood Arthritis Prospective Study (CAPS) Group 2022, ' No evidence that genetic predictors of susceptibility predict changes in core outcomes in JIA ', Rheumatology (Oxford, England) . https://doi.org/10.1093/rheumatology/keab942
- Accession number :
- edsair.doi.dedup.....888138fb981f6768f49c5ac1c2c3103d