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Global regulation by the seven-component Pi signaling system

Authors :
Yi-Ju Hsieh
Barry L. Wanner
Source :
Current Opinion in Microbiology. 13:198-203
Publication Year :
2010
Publisher :
Elsevier BV, 2010.

Abstract

This review concerns how Escherichia coli detects environmental inorganic orthophosphate (P(i)) to regulate genes of the phosphate (Pho) regulon by the PhoR/PhoB two-component system (TCS). P(i) control by the PhoR/PhoB TCS is a paradigm of a bacterial signal transduction pathway in which occupancy of a cell surface receptor(s) controls gene expression in the cytoplasm. The P(i) signaling pathway requires seven proteins, all of which probably interact in a membrane-associated signaling complex. Our latest studies show that P(i) signaling involves three distinct processes, which appear to correspond to different states of the sensory histidine kinase PhoR: an inhibition state, an activation state, and a deactivation state. We describe a revised model for P(i) signal transduction of the E. coli Pho regulon.

Details

ISSN :
13695274
Volume :
13
Database :
OpenAIRE
Journal :
Current Opinion in Microbiology
Accession number :
edsair.doi.dedup.....888035d89c75cc6e5784db6d6ea791fa
Full Text :
https://doi.org/10.1016/j.mib.2010.01.014