Back to Search
Start Over
Global regulation by the seven-component Pi signaling system
- Source :
- Current Opinion in Microbiology. 13:198-203
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- This review concerns how Escherichia coli detects environmental inorganic orthophosphate (P(i)) to regulate genes of the phosphate (Pho) regulon by the PhoR/PhoB two-component system (TCS). P(i) control by the PhoR/PhoB TCS is a paradigm of a bacterial signal transduction pathway in which occupancy of a cell surface receptor(s) controls gene expression in the cytoplasm. The P(i) signaling pathway requires seven proteins, all of which probably interact in a membrane-associated signaling complex. Our latest studies show that P(i) signaling involves three distinct processes, which appear to correspond to different states of the sensory histidine kinase PhoR: an inhibition state, an activation state, and a deactivation state. We describe a revised model for P(i) signal transduction of the E. coli Pho regulon.
- Subjects :
- inorganic chemicals
Microbiology (medical)
Regulation of gene expression
Escherichia coli Proteins
Histidine kinase
Gene Expression Regulation, Bacterial
Biology
medicine.disease_cause
Regulon
Microbiology
Article
Phosphates
Infectious Diseases
Bacterial Proteins
Biochemistry
Cytoplasm
Cell surface receptor
Gene expression
Escherichia coli
medicine
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 13695274
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Current Opinion in Microbiology
- Accession number :
- edsair.doi.dedup.....888035d89c75cc6e5784db6d6ea791fa
- Full Text :
- https://doi.org/10.1016/j.mib.2010.01.014