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Comparison of long non‑coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2013
-
Abstract
- Traditionally, cancer research has focused on protein-coding genes, which are considered the principal effectors and regulators of tumorigenesis. Non-coding RNAs, in particular microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have been widely reported to be important in the regulation of tumorigenesis and cancer development. However, to the best of our knowledge, investigation of the expression profiles of lncRNAs and a comparison of the involvement of lncRNAs, miRNAs and messenger RNAs (mRNAs) in esophageal tumorigenesis and development have not previously been performed. In the current study, intrinsic associations among the expression profiles of lncRNAs, miRNAs and mRNAs from normal esophageal tissues and those from cancer tissues were investigated. Oligonucleotide microarrays were used to detect the expression profiles of the three types of RNA in the canceration processes of human esophageal squamous cell carcinoma (ESCC) tissues. It was demonstrated that the different RNAs exhibit associated patterns of expression among normal esophageal epithelium, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia (HGIN), and carcinoma tissues, particularly in the critical period of canceration (HGIN to ESCC). Furthermore, the results indicated a high level of similarity in the potential function of lncRNAs, miRNAs and mRNAs in the processes of ESCC development. In the current study, a first generation atlas of lncRNA profiling and its association with miRNAs and mRNAs in the canceration processes of ESCC were presented.
- Subjects :
- Adult
Male
Cancer Research
Esophageal Neoplasms
Biology
medicine.disease_cause
Biochemistry
Transcriptome
microRNA
Genetics
medicine
Humans
RNA, Messenger
canceration processes
Molecular Biology
Gene
Aged
Neoplasm Staging
Oligonucleotide Array Sequence Analysis
Intraepithelial neoplasia
Oncogene
long non-coding RNA
messenger RNA
RNA
Computational Biology
Articles
Cell cycle
Middle Aged
Molecular biology
bioinformatic analysis
esophageal squamous cell carcinoma
MicroRNAs
Oncology
Cancer research
Carcinoma, Squamous Cell
Disease Progression
Molecular Medicine
Female
RNA, Long Noncoding
Carcinogenesis
Subjects
Details
- ISSN :
- 17913004
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular medicine reports
- Accession number :
- edsair.doi.dedup.....887d2d58274beaef353b9d2356f777ba