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Live-cell imaging and profiling of c-Jun N-terminal kinases using covalent inhibitor-derived probes
- Source :
- Chemical communications (Cambridge, England). 55(8)
- Publication Year :
- 2019
-
Abstract
- c-Jun N-terminal kinases (JNKs) are involved in critical cellular functions. Herein, small-molecule JNK-targeting probes are reported based on a covalent inhibitor. Together with newly developed two-photon fluorescence Turn-ON reporters and chemoproteomic studies, we showed that some probes may be suitable for live-cell imaging and profiling of JNKs.
- Subjects :
- Cellular functions
Catalysis
Small Molecule Libraries
Optical imaging
Live cell imaging
Materials Chemistry
Humans
Protein Kinase Inhibitors
Fluorescent Dyes
biology
Molecular Structure
Chemistry
Kinase
Optical Imaging
Metals and Alloys
JNK Mitogen-Activated Protein Kinases
General Chemistry
Fluorescence
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Biochemistry
c-Jun N-terminal kinases
Covalent bond
Ceramics and Composites
biology.protein
HeLa Cells
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 55
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....8879b18aa6bbb2119c6f15730b72d511