Disappearance of specific immune response after successful therapy of chronic Lyme borreliosis

512 consecutive patients suffering from chronic Lyme borreliosis have been treated according to a standardized therapy regimen which was developed using the results of a controlled trial (Hassler et al., 1990; Hassler, 1992). Follow up was performed for at least 6 (maximum 16) years. In the first two years after initial therapy clinical and serological data were collected every six months including Western blot testing, later once a year.