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Biomechanical properties of the repaired and non-repaired rat supraspinatus tendon in the acute postoperative period
- Source :
- Connective Tissue Research. 60:254-264
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- Purpose The rat rotator cuff (RC) model is used to study RC pathology and potential treatment; however, native scar-mediated healing allows the rat RC to recover at 4-6 weeks but little is known about acute healing. This study characterized the properties of the repaired and non-repaired rat RC following surgical detachment. Materials and methods Forty-eight rats underwent surgical RC detachment and received surgical repair (Repair) or left unrepaired (Defect) to either 12 or 19 days. Healthy controls were obtained from contralateral limbs. Biomechanical properties were assessed using stress relaxation and failure testing and mechanical modeling performed using quasilinear viscoelastic (QLV) and structurally based elastic models. Histology and micro-magnetic resonance imaging were used to qualitatively grade tendon-to-bone healing. Results Repair and Defect exhibited significantly inferior mechanical properties compared to Healthy at both time points. Repair had significant increases in peak, equilibrium, and ultimate stress, modulus, and stiffness and significant decreases in cross-sectional area, % relaxation, and QLV constant "C" between 12 and 19 days, whereas Defect showed no change. Conclusions This study demonstrates acute differences in mechanical properties of the rat supraspinatus tendon in the presence and absence of surgical repair. Understanding the longitudinal recovery of mechanical properties can facilitate more accurate characterization of RC pathology or future treatments.
- Subjects :
- medicine.medical_specialty
0206 medical engineering
02 engineering and technology
Models, Biological
Biochemistry
Supraspinatus tendon
Rats, Sprague-Dawley
Rotator Cuff
03 medical and health sciences
Rheumatology
Elastic Modulus
medicine
Animals
Orthopedics and Sports Medicine
Rotator cuff
Postoperative Period
Molecular Biology
030304 developmental biology
Surgical repair
Wound Healing
0303 health sciences
medicine.diagnostic_test
Viscosity
business.industry
Magnetic resonance imaging
Cell Biology
Magnetic Resonance Imaging
020601 biomedical engineering
Elasticity
Biomechanical Phenomena
Surgery
medicine.anatomical_structure
Ultimate stress
Female
Stress, Mechanical
Wound healing
business
Subjects
Details
- ISSN :
- 16078438 and 03008207
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Connective Tissue Research
- Accession number :
- edsair.doi.dedup.....8870a09a805894c05f4ad4ce79342b17