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Interstitial cystitis: a rare manifestation of primary Sjögren’s syndrome, successfully treated with low dose cyclosporine
- Source :
- Rheumatology International
- Publication Year :
- 2011
- Publisher :
- Springer-Verlag, 2011.
-
Abstract
- PubMed ID: 21258795<br />Chronic interstitial cystitis (IC), mostly affecting middle-aged women, is a very rare manifestation of primary Sjögren's syndrome (pSS). Hereby, we report a 42-year-old woman with pSS, presenting with dysuria, urinary frequency, and suprapubic pain. She was diagnosed to have chronic IC, based upon the cystoscopic biopsy finding of chronic inflammation in the bladder wall. Systemic corticosteroid and azathioprine treatments together with local intravesical therapies were not effective. Therefore, cyclosporine (CSA) therapy was initiated. Initial low dose of CSA (1.5 mg/kg/d) improved the symptoms of the patient, with no requirement for dose increment. After 4 months of therapy, control cystoscopic biopsy showed that bladder inflammation regressed and IC improved. This case suggests that even low doses of CSA may be beneficial for treating chronic IC associated with pSS syndrome. © 2011 Springer-Verlag.
- Subjects :
- Adult
medicine.medical_specialty
medicine.drug_class
Urinary system
Biopsy
Immunology
Urology
Cystitis, Interstitial
Azathioprine
Primary Sjögren’s syndrome
Interstitial cystitis
Rheumatology
Prednisone
medicine
Medicine & Public Health
Immunology and Allergy
Dysuria
Humans
medicine.diagnostic_test
business.industry
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
Cystoscopy
medicine.disease
Surgery
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS
ComputingMethodologies_PATTERNRECOGNITION
Sjogren's Syndrome
Treatment Outcome
Primary Sjögren's syndrome
Chronic Disease
Cyclosporine
Corticosteroid
Original Article
Drug Therapy, Combination
Female
InformationSystems_MISCELLANEOUS
medicine.symptom
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 1437160X and 01728172
- Volume :
- 32
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Rheumatology International
- Accession number :
- edsair.doi.dedup.....886f17e0ae06c32dde952c6ed323dd93