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Heterogeneity of PD-MCI in Candidates to Subthalamic Deep Brain Stimulation: Associated Cortical and Subcortical Modifications
- Source :
- Journal of Parkinson's disease, Journal of Parkinson's disease, 2022, 12 (5), pp.1507-1526. ⟨10.3233/JPD-223232⟩
- Publication Year :
- 2022
- Publisher :
- IOS Press, 2022.
-
Abstract
- International audience; Background: Parkinson’s disease mild cognitive impairment (PD-MCI) is frequent and heterogenous. There is no consensus about its influence on subthalamic deep brain stimulation (STN-DBS) outcomes. Objective: To determine the prevalence of PD-MCI and its subtypes in candidates to STN-DBS. Secondarily, we sought to identify MRI structural markers associated with cognitive impairment in these subgroups. Methods: Baseline data from the French multicentric PREDISTIM cohort were used. Candidates to STN-DBS were classified according to their cognitive performance in normal cognition (PD-NC) or PD-MCI. The latter included frontostriatal (PD-FS) and posterior cortical (PD-PC) subtypes. Between-group comparisons were performed on demographical and clinical variables as well as on T1-weighted MRI sequences at the cortical and subcortical levels. Results: 320 patients were included: 167 (52%) PD-NC and 153 (48%) PD-MCI patients. The latter group included 123 (80%) PD-FS and 30 (20%) PD-PC patients. There was no between-group difference regarding demographic and clinical variables. PD-PC patients had significantly lower global efficiency than PD-FS patients and significantly worse performance on visuospatial functions, episodic memory, and language. Compared to PD-NC, PD-MCI patients had cortical thinning and radiomic-based changes in the left caudate nucleus and hippocampus. There were no significant differences between the PD-MCI subtypes. Conclusion: Among the candidates to STN-DBS, a significant proportion has PD-MCI which is associated with cortical and subcortical alterations. Some PD-MCI patients have posterior cortical deficits, a subtype known to be at higher risk of dementia.
- Subjects :
- [SCCO.NEUR]Cognitive science/Neuroscience
Deep Brain Stimulation
shape analysis
Parkinson Disease
Magnetic Resonance Imaging
Cortical thickness
Cellular and Molecular Neuroscience
Cognition
radiomics
dual syndrome hypothesis
voxel-based morphometry
Humans
Cognitive Dysfunction
Neurology (clinical)
Subjects
Details
- ISSN :
- 1877718X and 18777171
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Parkinson's Disease
- Accession number :
- edsair.doi.dedup.....88522fd9a04ab06ed0c58a504155db15