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Analysis of GNA13 Protein in Follicular Lymphoma and its Association With Poor Prognosis
- Source :
- The American Journal of Surgical Pathology
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Supplemental Digital Content is available in the text.<br />GNA13 is a G protein involved in modulating tumor proliferative capacity, infiltration, metastasis, and migration. Genomic alteration of GNA13 was frequently observed in follicular lymphoma (FL). In this study, we examined 167 cases of FL by immunostaining of GNA13 using tissue microarray to evaluate the clinical significance. There were 26 GNA13-positive cases (15.6%) and 141 GNA13-negative cases (84.4%). GNA13-positive cases had a higher incidence of early progression of disease for which disease progression was recognized within 2 years compared with GNA13-negative cases (P=0.03). There were no significant differences in other clinicopathologic factors including histological grade, BCL2-IGH translocation, immunohistochemical phenotype, and Follicular Lymphoma International Prognostic Index. In addition, overall survival and progression-free survival were poorer in GNA13-positive cases than in GNA13-negative cases (P=0.009 and 0.005, respectively). In multivariate analysis, GNA13 positivity was found to be a poor prognostic factor for overall survival and progression-free survival. Thus, GNA13 protein expression was an independent prognostic factor and may affect disease progression in FL.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Time Factors
Follicular lymphoma
GNA13
GTP-Binding Protein alpha Subunits, G12-G13
Risk Assessment
Pathology and Forensic Medicine
Metastasis
03 medical and health sciences
International Prognostic Index
follicular lymphoma
Risk Factors
Internal medicine
Biomarkers, Tumor
medicine
Humans
Clinical significance
Progression-free survival
Lymphoma, Follicular
Aged
Aged, 80 and over
Tissue microarray
business.industry
Original Articles
Middle Aged
poor prognosis
medicine.disease
Immunohistochemistry
Progression-Free Survival
Lymphoma
030104 developmental biology
Tissue Array Analysis
ComputingMethodologies_DOCUMENTANDTEXTPROCESSING
Disease Progression
Cancer research
Female
Surgery
Anatomy
business
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....8850382753d19daea6c66f7f8302e12a