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Single Nucleotide Polymorphism in the Coding Region of Bovine Chemerin Gene and Their Associations with Carcass Traits in Japanese Black Cattle
- Source :
- Asian-Australasian Journal of Animal Sciences, Asian-Australasian Journal of Animal Sciences, Vol 28, Iss 8, Pp 1084-1089 (2015)
- Publication Year :
- 2015
- Publisher :
- Asian Australasian Association of Animal Production Societies, 2015.
-
Abstract
- Chemerin, highly expressed in adipose and liver tissues, regulates glucose and lipid metabolism and immunity in these tissues in ruminants and mice. Our previous reports showed that chemerin is involved in adipogenesis and lipid metabolism in adipose tissue as an adipokine. The aim of the present study was to identify single nucleotide polymorphisms (SNPs) in the coding region of the chemerin gene and to analyze their effects on carcass traits and intramuscular fatty acid compositions in Japanese Black cattle. The SNPs in the bovine chemerin gene were detected in 232 Japanese Black steers (n = 161) and heifers (n = 71) using DNA sequencing. The results revealed five novel silent mutations: NM_001046020: c.12A>G (4aa), c.165GT (92aa), c.321 A>G (107aa), and c.396C>T (132aa). There was no association between 4 of the SNPs (c.12A>G [4aa], c.165GG [107aa], and c.396C>T) and carcass traits or intramuscular fatty acid compositions. Regarding the remaining SNP, c.276C>T, we found that cattle with genotype CC had a higher beef marbling score than that of cattle with genotype CT, whereas cattle with genotype CT had a higher body condition score (pT SNP is small. It is suggested that the c.276C>T SNP of the chemerin gene has potential in cattle breeding using modern methods, such as marker assisted selection. So, further functional and physiological research elucidating the impact of the chemerin gene on bovine lipid metabolism including fatty acid synthesis will help in understanding these results.
- Subjects :
- medicine.medical_specialty
Marbled meat
lcsh:Animal biochemistry
Japanese Black Cattle
Adipose tissue
Single-nucleotide polymorphism
Article
Internal medicine
Genotype
medicine
Chemerin
lcsh:QP501-801
Gene
Carcass Trait
lcsh:SF1-1100
chemistry.chemical_classification
Genetics
biology
Fatty acid
Lipid metabolism
Endocrinology
chemistry
Single Nucleotide Polymorphism
biology.protein
Animal Science and Zoology
lcsh:Animal culture
Food Science
Subjects
Details
- ISSN :
- 19765517 and 10112367
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Asian-Australasian Journal of Animal Sciences
- Accession number :
- edsair.doi.dedup.....884db4ccb52fa1780e4abfe18f85decb