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Multi-omics approach to study global changes in a triclosan-resistant mutant strain of Acinetobacter baumannii ATCC 17978
- Source :
- International journal of antimicrobial agents. 49(1)
- Publication Year :
- 2016
-
Abstract
- Acinetobacter baumannii AB042, a triclosan-resistant mutant strain, was examined for modulated gene expression using whole-genome sequencing, transcriptomics and proteomics in order to understand the mechanism of triclosan resistance as well as its impact on A. baumannii. Data revealed modulated expression of the fatty acid metabolism pathway, co-factors known to play a role in the synthesis of fatty acids, as well as several transcriptional regulators. The membrane composition of the mutant revealed a decrease in C18 with a corresponding increase in C16 fatty acids compared with the parent strain A. baumannii ATCC 17978. These data indicate that A. baumannii responds to triclosan by altering the expression of genes involved in fatty acid metabolism, antibiotic resistance and amino acid metabolism.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Acinetobacter baumannii
Proteome
030106 microbiology
Mutant
Microbiology
03 medical and health sciences
chemistry.chemical_compound
Gene expression
Drug Resistance, Bacterial
Pharmacology (medical)
Gene
biology
Fatty acid metabolism
Gene Expression Profiling
Lipid metabolism
General Medicine
Sequence Analysis, DNA
biology.organism_classification
Lipid Metabolism
Triclosan
Gene expression profiling
030104 developmental biology
Infectious Diseases
chemistry
Biochemistry
Mutation
Anti-Infective Agents, Local
Genome, Bacterial
Metabolic Networks and Pathways
Subjects
Details
- ISSN :
- 18727913
- Volume :
- 49
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of antimicrobial agents
- Accession number :
- edsair.doi.dedup.....8849478be9e7c0096bb2df0745fc924a