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Modulation of dendritic cell function by Trichomonas vaginalis-derived secretory products
- Source :
- BMB Reports, BMB REPORTS(48): 2
- Publication Year :
- 2015
- Publisher :
- Korean Society for Biochemistry and Molecular Biology, 2015.
-
Abstract
- Trichomoniasis caused by the parasitic protozoan Trichomonas vaginalis is the most common sexually transmitted disease in the world. Dendritic cells are antigen presenting cells that initiate immune responses by directing the activation and differentiation of naïve T cells. In this study, we analyzed the effect of Trichomonas vaginalis-derived Secretory Products on the differentiation and function of dendritic cells. Differentiation of bone marrow-derived dendritic cells in the presence of T. vaginalis-derived Secretory Products resulted in inhibition of lipopolysaccharide-induced maturation of dendritic cells, down-regulation of IL-12, and up-regulation of IL-10. The protein components of T. vaginalis-derived Secretory Products were shown to be responsible for altered function of bone marrow-derived dendritic cells. Chromatin immunoprecipitation assay demonstrated that IL-12 expression was regulated at the chromatin level in T. vaginalis-derived Secretory Productstreated dendritic cells. Our results demonstrated that T. vaginalis-derived Secretory Products modulate the maturation and cytokine production of dendritic cells leading to immune tolerance. [BMB Reports 2015; 48(2): 103-108]
- Subjects :
- Lipopolysaccharides
Chromatin Immunoprecipitation
Cellular differentiation
Antigen presentation
Down-Regulation
Antigens, Protozoan
Bone Marrow Cells
Biochemistry
Immune tolerance
Mice
Trichomonas vaginalis
Animals
Antigen-presenting cell
Molecular Biology
Cytokine
CD40
Follicular dendritic cells
biology
Chromatin
Dendritic cells
Tolerance
Granulocyte-Macrophage Colony-Stimulating Factor
Cell Differentiation
General Medicine
Dendritic cell
Dendritic Cells
Interleukin-12
Cell biology
Interleukin-10
Up-Regulation
Mice, Inbred C57BL
biology.protein
Interleukin 12
Research-Article
Female
Endopeptidase K
Subjects
Details
- Language :
- English
- ISSN :
- 1976670X and 19766696
- Volume :
- 48
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- BMB Reports
- Accession number :
- edsair.doi.dedup.....883db0ec170f0ff02829950e67be6e7b