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Chiral AuI- and AuIII-isothiourea complexes : synthesis, characterization and application
- Publication Year :
- 2018
-
Abstract
- ADS thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. SPN thanks King Abdullah University of Science and Technology (Award No. SR-2015-CCF-1974-03) and King Saud University for support. During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold‐isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air‐ and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)‐isothiourea carbonyl complexes. The novel gold(I)‐ and gold(III)‐isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically‐relevant enzymes. Postprint
- Subjects :
- Steric effects
education
chemistry.chemical_element
Homogeneous catalysis
010402 general chemistry
01 natural sciences
Catalysis
Coordination complex
Bioinorganic chemistry
N ligands
SDG 3 - Good Health and Well-being
Synergistic catalysis
QD
Iridium
chemistry.chemical_classification
010405 organic chemistry
Organic Chemistry
DAS
General Chemistry
QD Chemistry
Combinatorial chemistry
0104 chemical sciences
Coordination chemistry
Enantiopure drug
chemistry
Organocatalysis
Gold
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....88386869ca7e1fc7009778bb5184bdbd