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Choline: Clinical Nutrigenetic/Nutrigenomic Approaches for Identification of Functions and Dietary Requirements
- Source :
- Journal of Nutrigenetics and Nutrigenomics. 3:209-219
- Publication Year :
- 2010
- Publisher :
- S. Karger AG, 2010.
-
Abstract
- Nutrigenetics/nutrigenomics (the study of the bidirectional interactions between genes and diet) is a rapidly developing field that is changing research and practice in human nutrition. Though eventually nutrition clinicians may be able to provide personalized nutrition recommendations, in the immediate future they are most likely to use this knowledge to improve dietary recommendations for populations. Currently, estimated average requirements are used to set dietary reference intakes because scientists cannot adequately identify subsets of the population that differ in requirement for a nutrient. Recommended intake levels must exceed the actual required intake for most of the population in order to assure that individuals with the highest requirement ingest adequate amounts of the nutrient. As a result, dietary reference intake levels often are set so high that diet guidelines suggest almost unattainable intakes of some foods. Once it is possible to identify common subgroups that differ in nutrient requirements using nutrigenetic/nutrigenomic profiling, targeted interventions and recommendations can be refined. In addition, when a large variance exists in response to a nutrient, statistical analyses often argue for a null effect. If responders could be differentiated from nonre-sponders based on nutrigenetic/nutrigenomic profiling, this statistical noise could be eliminated and the sensitivity of nutrition research greatly increased.
- Subjects :
- Paper
Population
Medicine (miscellaneous)
Biology
Polymorphism, Single Nucleotide
Article
Nutrigenetics
Choline
Epigenesis, Genetic
Fetal Development
chemistry.chemical_compound
Nutrigenomics
Nutrient
Genetics
Humans
Nutritional Physiological Phenomena
education
Nootropic Agents
education.field_of_study
Lipotropic Agents
business.industry
Gene Expression Profiling
Nutritional Requirements
Genetic Variation
Brain
Genomics
Choline Deficiency
Biotechnology
Human nutrition
chemistry
Dietary Reference Intake
Personalized nutrition
business
Food Science
Subjects
Details
- ISSN :
- 16616758 and 16616499
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Nutrigenetics and Nutrigenomics
- Accession number :
- edsair.doi.dedup.....8827ca8ff8ada05d7cc61ac11ad7af5f