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Cutaneous T-cell Lymphoma and Pruritus: The Expression of IL-31 and its Receptors in the Skin
- Source :
- Acta Dermato Venereologica. 96:894-898
- Publication Year :
- 2016
- Publisher :
- Medical Journals Sweden AB, 2016.
-
Abstract
- Approximately 88% of cutaneous T-cell lymphoma (CTCL) patients are affected by pruritus that responds poorly to current antipruritic therapies. Interleukin (IL)-31, a Th2 cytokine, has been found to be increased in the serum of CTCL patients and to correlate with itch severity. This study investigated the role of IL-31 and its receptors (IL-31 receptor-alpha [IL-31RA] and OSMRβ) in the skin of CTCL patients with mild versus moderate/severe pruritus. Expression levels of IL-31, IL-31RA, and OSMRβ in the skin were measured using immunohistochemistry and correlated to pruritus severity and disease stage. In CTCL patients with moderate/severe pruritus, IL-31 was significantly elevated in the epidermis and dermal infiltrate, while IL-31RA and OSMRβ were significantly elevated only in the epidermis. Furthermore, epidermal IL-31 levels correlated to itch severity. These results show that IL-31 may play a role in CTCL pruritus by exerting indirect effects on sensory nerves though epidermal neoplastic T-cells and keratinocytes to transmit itch.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Biopsy
Dermatology
Th2 cytokines
Severity of Illness Index
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Humans
Medicine
skin and connective tissue diseases
Receptor
Antipruritic
Aged
Oncostatin M Receptor beta Subunit
integumentary system
Epidermis (botany)
business.industry
Interleukins
Pruritus
Cutaneous T-cell lymphoma
Interleukin
Receptors, Interleukin
General Medicine
medicine.disease
Immunohistochemistry
Lymphoma, T-Cell, Cutaneous
Lymphoma
030104 developmental biology
Immunology
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00015555
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Acta Dermato Venereologica
- Accession number :
- edsair.doi.dedup.....88243ce6b3e8c5d7a4b86310c8aba20a