Back to Search
Start Over
Prevalence of non-alcoholic fatty liver and liver fibrosis in patients with moderate-severe psoriasis: A cross-sectional cohort study
- Source :
- The Australasian journal of dermatologyReferences. 61(2)
- Publication Year :
- 2019
-
Abstract
- Background/objectives Several studies have reported that non-alcoholic fatty liver disease (NAFLD) is more frequent in patients with psoriasis, but few have reviewed the presence of liver fibrosis in those patients. Methods Cross-sectional cohort, single-centre study, continuously selecting all patients with moderate-severe psoriasis seen at the Psoriasis Unit of a Tertiary Hospital. The grade of liver steatosis was assessed using liver ultrasound, and the quantity of liver fibrosis was graded using a transitional vibration-controlled elastography (Fibroscan®). Results A total of 71 patients (66.2% male) were included, with an average age of 46.6 years old. The maximum historical PASI average was 14.4 while the baseline PASI average at the time of the study was 2. A third (36%) of patients met the criteria for metabolic syndrome 52% of patients had steatosis; being male, having metabolic syndrome comorbidities, elevated AST/ALT enzymes, dyslipidemia and high initial PASI were significantly related. 14% of patients had moderate liver fibrosis (≥7.6 KPa). In 30% of them, no ultrasound liver steatosis was observed. Conclusions Elastography may be a useful tool along with ultrasound to evaluate liver disease in patients with psoriasis.
- Subjects :
- Adult
Male
medicine.medical_specialty
Dermatology
Gastroenterology
Cohort Studies
030207 dermatology & venereal diseases
03 medical and health sciences
Liver disease
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Internal medicine
Psoriasis
medicine
Humans
Metabolic Syndrome
business.industry
Fatty liver
Middle Aged
medicine.disease
Cross-Sectional Studies
030220 oncology & carcinogenesis
Cohort
Elasticity Imaging Techniques
Female
Metabolic syndrome
Steatosis
business
Dyslipidemia
Cohort study
Subjects
Details
- ISSN :
- 14400960
- Volume :
- 61
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Australasian journal of dermatologyReferences
- Accession number :
- edsair.doi.dedup.....881d5a2fc6e9d675345a8c765fdb6c84