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[Influence of Bases for External Medicines with Different Coatability and Water Retentivity on Wound Healing]
- Source :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 138(11)
- Publication Year :
- 2018
-
Abstract
- When selecting external medicines for the treatment of skin diseases, it is thought to be very important to consider differences in characteristics of their bases, because the bases may influence the clinical efficacy of the medicines. In this study, we investigated whether the differences in characteristics of three kinds of bases, white petrolatum, macrogol ointment, and aqueous gel affect wound healing. In vitro moisture permeability tests demonstrated that these bases have different characteristics in coatability and water retentivity, with the rank order of the intensity of coatability as white petrolatum>macrogol ointment>aqueous gel, and that of water retentivity as macrogol ointment>white petrolatum>aqueous gel. Similar rank order of these bases was observed for transepidermal water loss and stratum corneum water content in the dry skin on the abdomen of guinea pigs induced by topical application of acetone/ether mixture, followed by water. In addition, we found that treatment with macrogol ointment, but not white petrolatum or aqueous gel, significantly accelerated wound healing in rat skin, and that the contents of basic fibroblast growth factor and epidermal growth factor in the skin treated with macrogol ointment were significantly higher compared with non-treated skin. In conclusion, these results imply an important role of the bases of external medicines in the treatment of skin diseases.
- Subjects :
- Male
Chemical Phenomena
Petrolatum
Guinea Pigs
Pharmaceutical Science
Moisture permeability
Permeability
Polyethylene Glycols
Ointments
Rats, Sprague-Dawley
Ointment Bases
Dry skin
medicine
Stratum corneum
Animals
Clinical efficacy
White petrolatum
Skin
Pharmacology
Transepidermal water loss
Wound Healing
Aqueous solution
Chromatography
integumentary system
Epidermal Growth Factor
Chemistry
Water
medicine.drug_formulation_ingredient
medicine.anatomical_structure
Female
Fibroblast Growth Factor 2
medicine.symptom
Wound healing
Gels
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 13475231
- Volume :
- 138
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Accession number :
- edsair.doi.dedup.....8815646637de4faa54c0ec19fc1a089e