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GCF2/LRRFIP1 promotes colorectal cancer metastasis and liver invasion through integrin-dependent RhoA activation
- Source :
- Cancer Letters. 325:99-107
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The precise relationship between GCF2 expression and carcinogenesis has not yet been established. To clarify the metastatic potential of GCF2 in colorectal cancer, HT-29 cells stably suppressing GCF2 expression were injected into the spleens of severe combined immunodeficient (SCID) mice. GCF2 suppression reduced the number of metastatic foci in the liver and reduced fibronectin-induced cell adhesion, migration, and invasion. Downstream from the integrin signaling pathways, GCF2 regulates RhoA interaction with the RGS domain of Leukemia associated RhoGEF (LARG). Altogether, our results suggest that GCF2 plays an important role in colorectal cancer metastasis by regulating RhoA-induced cell adhesion, migration, and invasion.
- Subjects :
- Integrins
Cancer Research
RHOA
Colorectal cancer
Integrin
Biology
medicine.disease_cause
Metastasis
Mice
Cell Movement
Cell Adhesion
medicine
Animals
Guanine Nucleotide Exchange Factors
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Cell adhesion
Liver Neoplasms
RNA-Binding Proteins
medicine.disease
Fibronectins
Leukemia
Oncology
Focal Adhesion Kinase 1
Cancer research
biology.protein
Signal transduction
Colorectal Neoplasms
rhoA GTP-Binding Protein
Carcinogenesis
HT29 Cells
Rho Guanine Nucleotide Exchange Factors
Signal Transduction
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 325
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....88070a7eee4d157c3ff85f706d41977b