PROGNOSTIC SIGNIFICANCE OF DEIODINASE ENZYMES MRNA EXPRESSION IN BREAST CANCER

BACKGROUND Iodothyronine deiodinases type 1, 2 and 3 (DIO1, DIO2 and DIO3) are enzymes that activates and deactivate Thyroid Hormones (TH) maintaining their homeostasis at cellular level. Recent studies show a possible role of deiodinases in various cancers. In this manuscript; we used data mining analytical approach and studied the prognostic significance DIO1-3 in Breast Cancer. METHODS Prognostic values of DIO1-3 were predicted using the “Kaplan- Meier Plotter” (KM plotter) database for direct in silico validation in clinical cases of breast cancer patients. After extracting KM survival plots, Relapse Free Survival (RFS) were compared, and Hazard Ratio (HR) and log-rank p-values were calculated. RESULTS There was a significant change in RFS of ER-ve breast cancer patients, with high DIO1 and DIO2 expression. Further, ER+ve breast cancer with hormone therapy high expression of DIO3 results in significantly poor RFS. CONCLUSIONS We found limited potential of prognostic values of DIO1-3 in breast cancer. We conclude that in some subgroups of breast cancer, these findings may be beneficial as a companion diagnostic predicting more accurate breast cancer prognosis.