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Electroencephalographic features of discontinuous activity in anesthetized infants and children
- Source :
- PLoS ONE, Vol 14, Iss 10, p e0223324 (2019), PLoS ONE
- Publication Year :
- 2019
- Publisher :
- Public Library of Science (PLoS), 2019.
-
Abstract
- BackgroundDiscontinuous electroencephalographic activity in children is thought to reflect brain inactivation. Discontinuity has been observed in states of pathology, where it is predictive of adverse neurological outcome, as well as under general anesthesia. Though in preterm-infants discontinuity reflects normal brain development, less is known regarding its role in term children, particularly in the setting of general anesthesia. Here, we conduct a post-hoc exploratory analysis to investigate the spectral features of discontinuous activity in children under general anesthesia.MethodsWe previously recorded electroencephalography in children less than forty months of age under general anesthesia (n = 65). We characterized the relationship between age, anesthetic depth, and discontinuous activity, and used multitaper spectral methods to compare the power spectra of subjects with (n = 35) and without (n = 30) discontinuous activity. In the subjects with discontinuous activity, we examined the amplitude and power spectra associated with the discontinuities and analyzed how these variables varied with age.ResultsCumulative time of discontinuity was associated with increased anesthetic depth and younger age. In particular, age-matched children with discontinuity received higher doses of propofol during induction as compared with children without discontinuity. In the tens of seconds preceding the onset of discontinuous activity, there was a decrease in high-frequency power in children four months and older that could be visually observed with spectrograms. During discontinuous activity, there were distinctive patterns of amplitude, spectral edge, and power in canonical frequency bands that varied with age. Notably, there was a decline in spectral edge in the seconds immediately following each discontinuity.ConclusionDiscontinuous activity in children reflects a state of a younger or more deeply anesthetized brain, and characteristic features of discontinuous activity evolve with age and may reflect neurodevelopment.
- Subjects :
- Male
Younger age
Physiology
General Anesthesia
Electroencephalography
Classification of discontinuities
Audiology
Families
0302 clinical medicine
030202 anesthesiology
Anesthesiology
Medicine and Health Sciences
Anesthesia
Child
Children
Clinical Neurophysiology
Anesthesiology Monitoring
Brain Mapping
Multidisciplinary
medicine.diagnostic_test
Pharmaceutics
Brain
Drugs
Electrophysiology
Bioassays and Physiological Analysis
Brain Electrophysiology
Engineering and Technology
Medicine
Female
Propofol
Infants
Infant, Premature
medicine.drug
Research Article
medicine.medical_specialty
Brain development
Imaging Techniques
Science
Neurophysiology
Neuroimaging
Anesthesia, General
Research and Analysis Methods
03 medical and health sciences
Discontinuity (geotechnical engineering)
Drug Therapy
Multitaper
medicine
Humans
Pain Management
Electrodes
Retrospective Studies
Anesthetics
Pharmacology
business.industry
Electrophysiological Techniques
Infant, Newborn
Infant
Biology and Life Sciences
Age Groups
Anesthetic
People and Places
Population Groupings
Clinical Medicine
Electronics
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....87fce4b1ddc78917ae09a5e7009cbb0f