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Bradyarrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy
- Source :
- The American Journal of Cardiology. 123:1690-1695
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Less is known about bradyarrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC). This cross-sectional study aimed to assess the prevalence and clinical significance of bradyarrhythmias in ARVC. From May 1995 to December 2017, bradyarrhythmias including sick sinus syndrome, atrioventricular block, and intraventricular conductional block (ICB) were investigated in 522 ARVC patients. A total of 169 patients (32.4%) presented with bradyarrhythmias including sick sinus syndrome in18 (3.5%), atrioventricular block in 56 (10.7%), and ICB in 118 patients (22.6%). Multivariate analysis showed right atrial dilation increased the risk of bradyarrhythmias (odds ratio [OR] 1.641, 95% confidence interval [CI] 1.081 to 2.492, p= 0.020). Bradyarrhythmias were not associated with death and heart transplantation. In patients with bradyarrhythmias, female gender, left atrial diameter40 mm, and New York Heart Association Ⅲ/Ⅳ increased the risk of death and heart transplantation (hazards ratio [HR] = 2.790, 95% CI 1.220 to 6.377, p = 0.015; HR = 4.913, 95% CI 2.058 to 11.730, p0.001; HR = 3.223, 95% CI 1.246 to 8.340, p = 0.016). Among the 23 patients who underwent device implantation, left atrial diameter40mm was associated with death and heart transplantation (HR = 9.523, 95% CI 1.587 to 57.126, p = 0.014). In conclusion, bradyarrhythmias were commonly seen in ARVC, and ICB was the most common type. Female, left atrial diameter40 mm, and NYHA class were associated with death and heart transplantation.
- Subjects :
- Adult
Male
0301 basic medicine
China
medicine.medical_specialty
Heart Ventricles
medicine.medical_treatment
030204 cardiovascular system & hematology
Right ventricular cardiomyopathy
Sick sinus syndrome
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Bradycardia
Humans
Medicine
Heart Atria
Arrhythmogenic Right Ventricular Dysplasia
Retrospective Studies
Heart transplantation
medicine.diagnostic_test
business.industry
Incidence
Hazard ratio
Retrospective cohort study
Odds ratio
medicine.disease
Survival Rate
Cross-Sectional Studies
030104 developmental biology
Echocardiography
Ventricular Function, Right
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Atrioventricular block
Follow-Up Studies
Subjects
Details
- ISSN :
- 00029149
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- The American Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....87fb67c0804cc81b76206a82e88b09cc