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Comparison of the Effectiveness of Pharmacological Treatments for Patients with Chronic Low Back Pain: A Nationwide, Multicenter Study in Japan
- Source :
- Spine Surgery and Related Research, Spine Surgery and Related Research, Vol 5, Iss 4, Pp 252-263 (2021)
- Publication Year :
- 2021
- Publisher :
- Japanese Society for Spine Surgery and Related Research, 2021.
-
Abstract
- Introduction: Chronic low back pain (CLBP) is a leading cause of disability, yet there is limited high-quality evidence to identify the most suitable pharmacological therapy. The purpose of this Japanese nationwide, multicenter, prospective study was to compare the effectiveness of four representative drug therapies―acetaminophen, celecoxib, loxoprofen, and a tramadol and acetaminophen (T+A) combination drug―to establish evidence for a drug of choice for CLBP. Methods: Patients with CLBP (N=471) received one of the four treatments and were evaluated, prospectively and comprehensively, once every month for six months using a visual analog scale (VAS) for LBP, the Japanese Orthopedic Association (JOA) score, the JOA Back Pain Evaluation Questionnaire (JOABPEQ), the Roland-Morris Disability Questionnaire (RDQ), the EuroQol five-dimensions three-levels (EQ-5D-3L), and the Short Form-8 item health survey (SF-8). We conducted multivariable linear regression analyses of the four drugs at 1 and 6 months after drug allocation. Differences with P
- Subjects :
- medicine.medical_specialty
RD1-811
business.industry
Visual analogue scale
effectiveness
Loxoprofen
humanities
Acetaminophen
pharmacological treatment
Internal medicine
Orthopedic surgery
chronic low back pain
analgesics
medicine
Celecoxib
Back pain
Original Article
Orthopedics and Sports Medicine
Surgery
Neurology (clinical)
Tramadol
medicine.symptom
business
Prospective cohort study
medicine.drug
Subjects
Details
- ISSN :
- 2432261X
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Spine Surgery and Related Research
- Accession number :
- edsair.doi.dedup.....87edc57c2222f979b00623db09885d91