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Mechanically matching the rheological properties of brain tissue for drug-delivery in human glioblastoma models
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Peptide functionalized hyaluronic acid (HA CF) cross-linked by cucurbit[8]uril (CB[8]), a new class of drug-delivery reservoirs, is used to enable improved drug bioavailability for glioblastoma tumors in patient-derived xenograft (PDX) models. The mechanical and viscoelastic properties of native human and mouse tissues are measured over 8 h via oscillatory rheology under physiological conditions . Treatment with drug–loaded hydrogels allowed for a significant survival impact of 45 % (55.5–80.5 days). A relationship between the type of PDX tumor formed—a consequence of the heterogeneic nature of GB tumors—and changes in the initial survival is observed owing to greater local pressure from stiffer tumors. These biocompatible and tailorable materials warrant use as drug delivery reservoirs in PDX resection models, where the mechanical properties can be readily adjusted to match the stiffness of local tissue and thus have potential to improve the survival of GB patients.
- Subjects :
- Hyaluronic acid
Biophysics
Bioengineering
Peptide
02 engineering and technology
Brain tissue
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Mice
Drug Delivery Systems
Rheology
medicine
Animals
Humans
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
Brain
Hydrogels
021001 nanoscience & nanotechnology
medicine.disease
Drug-delivery
Bioavailability
Hydrogel
chemistry
Mechanics of Materials
Self-healing hydrogels
Drug delivery
Ceramics and Composites
Cancer research
Cucurbit[8]uril
0210 nano-technology
Glioblastoma
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....87e30c489ea63b16b53a2baf109db6b1
- Full Text :
- https://doi.org/10.17863/cam.71103