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Ultrasmall Barium Titanate Nanoparticles for Highly Efficient Hypoxic Tumor Therapy via Ultrasound Triggered Piezocatalysis and Water Splitting
- Source :
- ACS Nano. 15:11326-11340
- Publication Year :
- 2021
- Publisher :
- American Chemical Society (ACS), 2021.
-
Abstract
- Hypoxia in a solid tumor microenvironment (TME) can lead to the overexpression of hypoxia-inducible factor-1α (HIF-1α), which correlates to tumor metastasis. Reactive oxygen species (ROS) induced tumor cell apoptosis is becoming a promising method in tumor treatment. Currently, the ROS generating systems, e.g., photodynamic treatment and sonodynamic treatment, highly depend on oxygen (Osub2/sub) in the tumor microenvironment (TME). However, the level of Osub2/subin TME is too low to produce enough ROS. Herein, we developed an ultrasmall DSPE-PEGsub2000/subcoated barium titanate nanoparticle (P-BTO) for tumor treatment based on ultrasound triggered piezocatalysis and water splitting. Interestingly, irradiated by ultrasound, the surface of ultasmall P-BTO nanoparticles produced imbalance charges, which induced a cascade of redox reaction processes to simultaneously generate ROS and Osub2/sub, the latter one was hardly generated in large-sized barium titanate nanoparticles. The as-synthesized P-BTO reached the highest accumulation in the tumor site at 4 h after intravenous injection. The results showed that the produced Osub2/subsignificantly alleviated the hypoxia of TME to down-regulate the expression of HIF-1α, and the produced ROS can efficiently kill tumor cells. Moreover, the tumor metastasis was also inhibited, providing a different way to treat triple-negative breast cancer, which was easily metastatic and lacked effective treatments in the clinic.
- Subjects :
- General Physics and Astronomy
Nanoparticle
chemistry.chemical_element
02 engineering and technology
010402 general chemistry
01 natural sciences
Redox
Oxygen
Metastasis
chemistry.chemical_compound
Neoplasms
Cell Line, Tumor
Tumor Microenvironment
medicine
Humans
General Materials Science
Hypoxia
chemistry.chemical_classification
Reactive oxygen species
Tumor microenvironment
General Engineering
Water
Hypoxia (medical)
021001 nanoscience & nanotechnology
medicine.disease
0104 chemical sciences
chemistry
Barium
Barium titanate
Cancer research
Nanoparticles
medicine.symptom
Reactive Oxygen Species
0210 nano-technology
Subjects
Details
- ISSN :
- 1936086X and 19360851
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- ACS Nano
- Accession number :
- edsair.doi.dedup.....87dc4025712a9b36bfc65f16b7a66383