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The influence of manganese treatment on the distribution of metal elements in rats and the protection by sodium para-amino salicylic acid
- Source :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 36
- Publication Year :
- 2015
-
Abstract
- Manganese (Mn) overexposure induced neurological damages, which could be potentially protected by sodium para-aminosalicylic acid (PAS-Na). In this study, we systematically detected the changes of divalent metal elements in most of the organs and analyzed the distribution of the metals in Mn-exposed rats and the protection by PAS-Na. Sprague Dawley (SD) rats received intraperitoneal injections of 15mg/kg MnCl2·4H2O (5d/week for 3 weeks), followed by subcutaneous (back) injections of PAS-Na (100 and 200mg/kg, everyday for 5 weeks). The concentrations of Mn and other metal elements [Iron (Fe), Copper (Cu), Zinc (Zn), Magnesium (Mg), Calcium (Ca)] in major organs (liver, spleen, kidney, thighbone and iliac bone, cerebral cortex, hippocampus and testes) and blood by Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES). The results showed that Mn overexposure significantly increased Mn in most organs, Fe and Zn in liver, Fe and Mg in blood; however decreased Fe, Cu, Zn, Mg and Ca in cortex, Cu and Zn in kidney, Cu and Mg in iliac bone, and Zn in blood. In contrast, PAS-Na treatment restored most changes particularly in cortex. In conclusion, excessive Mn exposure disturbed the balance of other metal elements but PAS-Na post-treatments could restore these alterations.
- Subjects :
- 0301 basic medicine
Male
Sodium
Injections, Subcutaneous
Inorganic chemistry
chemistry.chemical_element
Zinc
Manganese
Calcium
Biochemistry
Inorganic Chemistry
Metal
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Manganism
medicine
Animals
Kidney
Magnesium
medicine.disease
Aminosalicylic Acid
Rats
030104 developmental biology
medicine.anatomical_structure
chemistry
Metals
visual_art
visual_art.visual_art_medium
Molecular Medicine
030217 neurology & neurosurgery
Injections, Intraperitoneal
Nuclear chemistry
Subjects
Details
- ISSN :
- 18783252
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
- Accession number :
- edsair.doi.dedup.....87d3e13bb1d73e44f59ebae1ae7f05b8