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Blood Procalcitonin Level as a Diagnostic Marker of Pediatric Bacterial Meningitis: A Systematic Review and Meta-Analysis
- Source :
- Diagnostics, Vol 11, Iss 846, p 846 (2021), Diagnostics
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Early diagnosis and treatment of bacterial meningitis in children are essential, due to the high mortality and morbidity rates. However, lumbar puncture is often difficult, and cerebrospinal fluid (CSF) culture takes time. This meta-analysis aims to determine the diagnostic accuracy of blood procalcitonin for detecting bacterial meningitis in children. We conducted a systematic search on electronic databases to identify relevant studies. Pooled sensitivity, specificity, and diagnostic odds ratio (DOR) were calculated, and a hierarchical summary receiver operating characteristic curve and area under the curve (AUC) were determined. Eighteen studies with 1462 children were included in the analysis. The pooled sensitivity, specificity, and the DOR of blood procalcitonin for detecting bacterial meningitis were 0.87 (95% confidence interval (CI): 0.78–0.93); 0.85 (95% CI: 0.75–0.91), and 35.85 (95% CI: 10.68–120.28), respectively. The AUC for blood procalcitonin was 0.921. Blood procalcitonin also showed higher diagnostic accuracy for detecting bacterial meningitis than other conventional biomarkers, including serum C-reactive protein and leukocyte count, CSF leukocyte and neutrophil count, and CSF protein and glucose levels. Blood procalcitonin can be a good supplemental biomarker with high diagnostic accuracy in detecting bacterial meningitis in children.
- Subjects :
- medicine.medical_specialty
Medicine (General)
diagnosis
Clinical Biochemistry
Review
Gastroenterology
Procalcitonin
03 medical and health sciences
0302 clinical medicine
R5-920
children
systematic review
030225 pediatrics
Internal medicine
medicine
030212 general & internal medicine
CSF albumin
medicine.diagnostic_test
Receiver operating characteristic
Lumbar puncture
business.industry
Area under the curve
meta-analysis
Absolute neutrophil count
Diagnostic odds ratio
Biomarker (medicine)
business
bacterial meningitis
procalcitonin
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 11
- Issue :
- 846
- Database :
- OpenAIRE
- Journal :
- Diagnostics
- Accession number :
- edsair.doi.dedup.....87d1baa38f78f578fc109d492f228aa8