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Aortic pulsatility drives microvascular organ damage in essential hypertension: New evidence from choroidal thickness assessment
- Source :
- Journal of Clinical Hypertension, Journal of Clinical Hypertension, Wiley, 2021, 23 (5), pp.1039-1040. ⟨10.1111/jch.14195⟩, The Journal of Clinical Hypertension
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Controversy exists about the association of choroidal thickness (CTh) with blood pressure (BP) values. There is some evidence suggesting that central hemodynamics changes are associated with microvascular disease. Our study was aimed to assess the relationships between CTh and clinic and 24-h BP and between CTh and estimated 24-h aortic pulse pressure (aPP), 24-h aortic systolic BP (aSBP), and 24-h aortic augmentation index (aAIx) in a group of hypertensive patients. We enrolled 158 hypertensive subjects (mean age 48 ± 13 years) all of which underwent evaluation of the choroidal district by Swept-Source optical coherence tomography (SS-OCT) and 24-h BP monitoring, in order to measure peripheral BP and to estimate central hemodynamic parameters. Inverse significant correlations of clinic PP, 24-h aPP, 24-h aSBP, and 24-h aAIx with thicknesses of central ring, inner ring, and outer ring of the choroid and its overall average were found. The strongest of these correlations was that relating 24-h aPP with overall average choroidal thickness (r = -.531; P .001). When we divided the study population in subjects with 24-h aPP above and below the median value (35 mm Hg), CTh were thinner in subjects with higher values of 24-aPP as compared to those with lower ones, even after adjustment for age, and other potential confounders. The relationships of CTh with 24-h aPP remained significant also taking into account the effects of various covariates in linear multiple regression analyses. Our findings support the concept of a cross-talk between macro- and microcirculation.
- Subjects :
- Adult
MESH: Hemodynamics
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Endocrinology, Diabetes and Metabolism
MEDLINE
Hemodynamics
Blood Pressure
030204 cardiovascular system & hematology
Essential hypertension
MESH: Choroid
MESH: Hypertension
03 medical and health sciences
0302 clinical medicine
Text mining
Internal medicine
medicine.artery
Internal Medicine
Humans
Medicine
030212 general & internal medicine
Hypertension diagnosis
ComputingMilieux_MISCELLANEOUS
Aorta
MESH: Humans
Choroid
business.industry
Blood Pressure Determination
MESH: Aorta
Middle Aged
medicine.disease
Organ damage
MESH: Essential Hypertension
Cross-Sectional Studies
Hypertension
Commentary
Cardiology
Cardiology and Cardiovascular Medicine
business
Pulsatile Haemodynamics
Subjects
Details
- ISSN :
- 17517176 and 15246175
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Hypertension
- Accession number :
- edsair.doi.dedup.....87d0d982162c54a0d7a26a06efef8edc
- Full Text :
- https://doi.org/10.1111/jch.14195