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In silico and in vivo investigations using an endocavitary photoplethysmography sensor for tissue viability monitoring
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2020
- Publisher :
- Society of Photo-optical Instrumentation Engineers, 2020.
-
Abstract
- SIGNIFICANCE: Colorectal cancer is one of the major causes of cancer-related deaths worldwide. Surgical removal of the cancerous growth is the primary treatment for this disease. A colorectal cancer surgery, however, is often unsuccessful due to the anastomotic failure that may occur following the surgical incision. Prevention of an anastomotic failure requires continuous monitoring of intestinal tissue viability during and after colorectal surgery. To date, no clinical technology exists for the dynamic and continuous monitoring of the intestinal perfusion.\ud \ud AIM: A dual-wavelength indwelling bowel photoplethysmography (PPG) sensor for the continuous monitoring of intestinal viability was proposed and characterized through a set of in silico and in vivo investigations.\ud \ud APPROACH: The in silico investigation was based on a Monte Carlo model that was executed to quantify the variables such as penetration depth and detected intensity with respect to the sensor-tissue separations and tissue perfusion. Utilizing the simulated information, an indwelling reflectance PPG sensor was designed and tested on 20 healthy volunteers. Two sets of in vivo studies were performed using the driving current intensities 20 and 40 mA for a comparative analysis, using buccal tissue as a proxy tissue-site.\ud \ud RESULTS: Both simulated and experimental results showed the efficacy of the sensor to acquire good signals through the "contact" to a "noncontact" separation of 5 mm. A very slow wavelength-dependent variation was shown in the detected intensity at the normal and hypoxic states of the tissue, whereas a decay in the intensity was found with the increasing submucosal-blood volume. The simulated detected-to-incident-photon-ratio and the experimental signal-to-noise ratio exhibited strong positive correlations, with the Pearson product-moment correlation coefficient R ranging between 0.65 and 0.87.\ud \ud CONCLUSIONS: The detailed feasibility analysis presented will lead to clinical trials utilizing the proposed sensor.
- Subjects :
- Male
TK
Biosensing Techniques
Signal-To-Noise Ratio
01 natural sciences
0903 Biomedical Engineering
PERFUSION
Medicine
Monte Carlo
Continuous monitoring
Radiology, Nuclear Medicine & Medical Imaging
Signal Processing, Computer-Assisted
OPTICAL-PROPERTIES
Equipment Design
Atomic and Molecular Physics, and Optics
Colorectal surgery
Electronic, Optical and Magnetic Materials
1113 Opthalmology and Optometry
Physical Sciences
Female
Surgical incision
Perfusion
Life Sciences & Biomedicine
Monte Carlo Method
Preclinical imaging
Paper
Adult
medicine.medical_specialty
Biochemistry & Molecular Biology
Adolescent
0205 Optical Physics
Biomedical Engineering
Biochemical Research Methods
RC0254
010309 optics
Biomaterials
Young Adult
In vivo
Photoplethysmogram
0103 physical sciences
Humans
Photoplethysmography
Monitoring, Physiologic
Tissue Survival
Science & Technology
business.industry
Mouth Mucosa
Optics
penetration depth
Intensity (physics)
Oxygen
endocavitary sensor
Sensing
business
RC
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....87cda6d038f43b476995d633e782b73a