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A Concise Total Synthesis of Deoxyschizandrin and Exploration of Its Antiproliferative Effects and those of Structurally Related Derivatives
- Source :
- Chemistry - A European Journal. 18:3193-3198
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- The natural product deoxyschizandrin has been shown to have a wide range of biological activities. In recent years the therapeutic potential of this compound against cancers has attracted significant interest. Herein we describe a concise de novo total synthesis of deoxyschizandrin based around a double organocuprate oxidation strategy. In addition, we present the results of biological studies exploring the ability of deoxyschizandrin and synthetic precursors lacking the medium ring biaryl unit to inhibit the proliferation of a human cancer cell line. These studies led to the identification of a structurally novel agent with in vitro anticancer activity.
- Subjects :
- Biological studies
Natural product
Molecular Structure
Stereochemistry
Organic Chemistry
Deoxyschizandrin
Total synthesis
General Chemistry
Related derivatives
Antineoplastic Agents, Phytogenic
Combinatorial chemistry
Lignans
Catalysis
In vitro
Cyclooctanes
chemistry.chemical_compound
C c coupling
chemistry
Cell Line, Tumor
Humans
Polycyclic Compounds
Drug Screening Assays, Antitumor
Human cancer
Cell Proliferation
Subjects
Details
- ISSN :
- 09476539
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Chemistry - A European Journal
- Accession number :
- edsair.doi.dedup.....87cbecb93795233189c797a8c423de8d