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Styrene Metabolism, Genotoxicity, and Potential Carcinogenicity
- Source :
- Drug Metabolism Reviews. 38:805-853
- Publication Year :
- 2006
- Publisher :
- Informa UK Limited, 2006.
-
Abstract
- This report reviews styrene biotransformation, including minor metabolic routes, and relates metabolism to the genotoxic effects and possible styrene-related carcinogenicity. Styrene is shown to require metabolic activation in order to become notably genotoxic and styrene 7,8-oxide is shown to contribute quantitatively by far the most (in humans more than 95%) to the genotoxicity of styrene, while minor ring oxidation products are also shown to contribute to local toxicities, especially in the respiratory system. Individual susceptibility depending on metabolism polymorphisms and individual DNA repair capacity as well as the dependence of the nonlinearity of the dose-response relationships in the species in question and the consequences for risk evaluation are analyzd.
- Subjects :
- Individual susceptibility
DNA repair
Styrene metabolism
DNA
Metabolism
Biology
medicine.disease_cause
Styrenes
Styrene
DNA Adducts
chemistry.chemical_compound
Biochemistry
chemistry
Biotransformation
Carcinogens
medicine
Animals
Humans
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Genotoxicity
Carcinogen
DNA Damage
Mutagens
Subjects
Details
- ISSN :
- 10979883 and 03602532
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Drug Metabolism Reviews
- Accession number :
- edsair.doi.dedup.....87c31416fb0ad8db975f76dbb345fa30