Additional file 1 of Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study

Additional file 1: e-Table 1: Percentage of missing values. e-Appendix 1: Multiple imputations of missing data and technique break down. e-Figure 1: Multiple imputation - convergence plots. e-Figure 2: Multiple imputation - distribution plots. e-Table 2: Imputation model fit. e-Appendix 2: Extended Statistical Methodology. e-Figure 3: Covariate balancing models - model fit comparison. e-Figure 4: Covariate balancing models - weights comparison. e-Appendix 3: Study information. e-Table 3: Overall un-balanced population. e-Table 4: Un-balanced study population. e-Figure 5: Final covariance balancing model - model fit. e-Figure 6: Final covariate balancing model - individual variable distributions. e-Figure 7: Final covariate balancing model - model weights. e-Figure 8: Static compliance versus time from ICU admission until intubation. e-Figure 9: Driving pressure versus time from ICU admission until intubation. e-Figure 10: PaO2/ FiO2 ratio versus time from ICU admission until intubation. e-Figure 11: Cox time varying model for influence of time until intubation on ICU mortality. e-Figure 12: Multivariable Cox proportional hazards model for in-ICU mortality (overall and covariance balanced). e-Figure 13: Multivariable Cox proportional hazards model for in-ICU mortality (only intubated and covariance balanced). e-Figure 14: Kaplan-Meier curve for ICU mortality ��� compliance vs. D-dimers. e-Figure 15: Kaplan-Meier curve for ICU mortality in unbalanced population. e-Table 5: Cox mixed-effects model with between-center random effects term (unbalanced). e-Figure 16: Multivariable Cox proportional hazards model for in-ICU mortality (overall and unbalanced). e-Figure 17: Multivariable Cox proportional hazards model for in-ICU mortality (only intubated and unbalanced). e-Figure 18: Multivariable Cox mixed-effects model with between-center random effects term for in-ICU mortality (overall study population ��� unbalanced). e-Figure 19: Multivariable Cox mixed-effects model with between-center random effects term for in-ICU mortality (only intubated ��� unbalanced). e-Appendix 4: Formulas.