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Genetic studies of focal segmental glomerulosclerosis: a waste of scientific time?
- Source :
- Pediatric Nephrology (Berlin, Germany)
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- Many genetic causes of focal segmental glomerulosclerosis (FSGS) have been described. A paradox is that the science in the molecular biology, which generally appears of high quality, is not mirrored by a similarly critical analysis of the renal pathology. FSGS has been applied to such a wide range of conditions that it can reasonably be said to have no useful meaning. Attempts to refine the term have been largely ignored. Study of 252 papers on genetic causes of FSGS found various clinical features. Many papers took the reported diagnosis without question. Few papers reported a pathological review, almost half reported FSGS and up to six other conditions caused by any particular gene, some reported FSGS with recognisable glomerular disorders, over 80% did not apply the Columbia classification, and in nearly all with photomicrographs, the images were not useful for refinement of FSGS. Some workers commented on a lack of genotype-phenotype correlation. One reason is a disregard of the principle that scientific investigation requires an unambiguous definition of the condition studied, to allow others to replicate or refute the findings. Genetic studies of FSGS should use a similarly rigorous approach to renal pathology to that used in molecular biology. Electronic supplementary material The online version of this article (10.1007/s00467-018-4161-6) contains supplementary material, which is available to authorized users.
- Subjects :
- Kidney Glomerulus
030232 urology & nephrology
Focal segmental glomerulosclerosis
Review
030204 cardiovascular system & hematology
urologic and male genital diseases
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Genetics
medicine
Humans
Genetic Testing
Pathological
Genetic Association Studies
Glomerulosclerosis, Focal Segmental
urogenital system
business.industry
Renal pathology
medicine.disease
female genital diseases and pregnancy complications
Research Design
Nephrology
Pediatrics, Perinatology and Child Health
business
Subjects
Details
- ISSN :
- 1432198X and 0931041X
- Volume :
- 35
- Database :
- OpenAIRE
- Journal :
- Pediatric Nephrology
- Accession number :
- edsair.doi.dedup.....87b03c517071aff5a251aba36f796605
- Full Text :
- https://doi.org/10.1007/s00467-018-4161-6