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Medicinal Activities and Nanomedicine Delivery Strategies for Brucea javanica Oil and Its Molecular Components
- Source :
- Molecules, Molecules, Vol 25, Iss 5414, p 5414 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Brucea javanica oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. An introduction to the composition and medicinal activities of BJO and its molecular components, including quassinoids and fatty acids, is first provided. Application examples involving each type of drug delivery vehicle are then critically presented. Future opportunities for nanomedicine delivery strategies in the field are also discussed and considered within the context of translational medicine needs and drug development processes.
- Subjects :
- Brucea javanica oil
ved/biology.organism_classification_rank.species
Quassinoid
Pharmaceutical Science
Context (language use)
Review
Analytical Chemistry
lcsh:QD241-441
03 medical and health sciences
0302 clinical medicine
Drug Delivery Systems
lcsh:Organic chemistry
Brucea Javanica Oil
Drug Discovery
Brucea
Medicine
Animals
Humans
Plant Oils
Physical and Theoretical Chemistry
030304 developmental biology
emulsion
0303 health sciences
Drug Carriers
Traditional medicine
Materials [Engineering]
ved/biology
business.industry
Organic Chemistry
Translational medicine
medicinal activity
nanomedicine
Lipids
spongosome
Brucea javanica
Drug development
Chemistry (miscellaneous)
030220 oncology & carcinogenesis
quassinoid
Drug delivery
liposome
drug delivery
Molecular Medicine
Nanomedicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 25
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....87aff848b357f5738740958160f16346