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Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis
- Source :
- Journal of Neurology, Neurosurgery, and Psychiatry, Abrahamyan, Sargis; Eberspächer, Bettina; Hoshi, Muna-Miriam; Aly, Lilian; Luessi, Felix; Groppa, Sergiu; Klotz, Luisa; Meuth, Sven G; Schroeder, Christoph; Grüter, Thomas; Tackenberg, Björn; Paul, Friedemann; Then-Bergh, Florian; Kümpfel, Tania; Weber, Frank; Stangel, Martin; Bayas, Antonios; Wildemann, Brigitte; Heesen, Christoph; Zettl, Uwe; ... (2020). Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry, 91(7), pp. 681-686. BMJ Publishing Group 10.1136/jnnp-2020-322941
- Publication Year :
- 2020
-
Abstract
- ObjectiveTo determine the prevalence of antibodies to Epstein-Barr virus (EBV) in a large cohort of patients with early multiple sclerosis (MS).MethodsSerum samples were collected from 901 patients with a clinically isolated syndrome (CIS) or early relapsing–remitting multiple sclerosis (RRMS) participating in the German National MS cohort, a prospective cohort of patients with early MS with stringent inclusion criteria. Epstein-Barr nuclear antigen (EBNA)-1 and viral capsid antigen (VCA) antibodies were measured in diluted sera by chemiluminescence immunoassays (CLIAs). Sera of EBNA-1 and VCA antibody-negative patients were retested undiluted by an EBV IgG immunoblot. For comparison, we retrospectively analysed the EBV seroprevalence across different age cohorts, ranging from 0 to >80 years, in a large hospital population (N=16 163) from Berlin/Northern Germany.ResultsEBNA-1 antibodies were detected by CLIA in 839 of 901 patients with CIS/RRMS. Of the 62 patients without EBNA-1 antibodies, 45 had antibodies to VCA as detected by CLIA. In all of the remaining 17 patients, antibodies to EBV were detected by immunoblot. Altogether, 901 of 901 (100%) patients with CIS/RRMS were EBV-seropositive. EBV seropositivity increased with age in the hospital population but did not reach 100% in any of the investigated age cohorts.ConclusionThe complete EBV seropositivity in this large cohort of patients with early MS strengthens the evidence for a role of EBV in MS. It also suggests that a negative EBV serology in patients with suspected inflammatory central nervous system disease should alert clinicians to consider diagnoses other than MS.
- Subjects :
- Adult
Male
Herpesvirus 4, Human
Multiple Sclerosis
610 Medicine & health
medicine.disease_cause
Antibodies, Viral
Serology
03 medical and health sciences
0302 clinical medicine
Antigen
Seroepidemiologic Studies
hemic and lymphatic diseases
Germany
medicine
Seroprevalence
Humans
Registries
ddc:610
Prospective cohort study
030304 developmental biology
Retrospective Studies
0303 health sciences
Clinically isolated syndrome
business.industry
Multiple sclerosis
Middle Aged
medicine.disease
Epstein–Barr virus
ddc
Psychiatry and Mental health
Immunology
Cohort
Surgery
Female
Neurology (clinical)
Function and Dysfunction of the Nervous System
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology, Neurosurgery, and Psychiatry, Abrahamyan, Sargis; Eberspächer, Bettina; Hoshi, Muna-Miriam; Aly, Lilian; Luessi, Felix; Groppa, Sergiu; Klotz, Luisa; Meuth, Sven G; Schroeder, Christoph; Grüter, Thomas; Tackenberg, Björn; Paul, Friedemann; Then-Bergh, Florian; Kümpfel, Tania; Weber, Frank; Stangel, Martin; Bayas, Antonios; Wildemann, Brigitte; Heesen, Christoph; Zettl, Uwe; ... (2020). Complete Epstein-Barr virus seropositivity in a large cohort of patients with early multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry, 91(7), pp. 681-686. BMJ Publishing Group 10.1136/jnnp-2020-322941 <http://dx.doi.org/10.1136/jnnp-2020-322941>
- Accession number :
- edsair.doi.dedup.....87ab1c1d9a16c49e3c0939c8d942728a