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Association analysis of HSP90B1 with bipolar disorder
- Source :
- Journal of Human Genetics. 52:794-803
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Pathophysiological role of endoplasmic reticulum (ER) stress response signaling has been suggested for bipolar disorder. The goal of this study was to test the genetic association between bipolar disorder and an ER chaperone gene, HSP90B1 (GRP94/gp96), which is located on a candidate locus, 12q23.3. We tested the genetic association between bipolar disorder and HSP90B1 by case-control studies in two independent Japanese sample sets and by a transmission disequilibrium test (TDT) in NIMH Genetics initiative bipolar trio samples (NIMH trios). We also performed gene expression analysis of HSP90B1 in lymphoblastoid cells. Among the 11 SNPs tested, rs17034977 showed significant association in both Japanese sample sets. The frequency of the SNP was lower in NIMH samples than in Japanese samples and there was no significant association in NIMH trios. Gene expression analysis of HSP90B1 in lymphoblastoid cells suggested a possible relationship between the associated SNP and mRNA levels. HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population, though further study will be needed to understand the underlying functional mechanisms.
- Subjects :
- Adult
Male
Bipolar Disorder
Gene Expression
Single-nucleotide polymorphism
Biology
Polymorphism, Single Nucleotide
Asian People
mental disorders
Gene expression
Genetics
medicine
Humans
SNP
HSP90 Heat-Shock Proteins
RNA, Messenger
Bipolar disorder
Gene
Genetics (clinical)
Genetic association
Polymorphism, Genetic
Transmission disequilibrium test
Middle Aged
medicine.disease
Mrna level
Schizophrenia
Female
Subjects
Details
- ISSN :
- 1435232X and 14345161
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....87a885df090047fd8fa40f23dbf1ccd5