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Chrysospermins, new peptaibol antibiotics from Apiocrea chrysosperma Ap101
- Source :
- The Journal of antibiotics. 48(9)
- Publication Year :
- 1995
-
Abstract
- Four new members of peptaibol antibiotics, designated as chrysospermins A, B, C, and D, were isolated from the mycelium of Apiocrea chrysosperma Ap101 by solvent extraction, silica gel chromatography and preparative recycling HPLC. Their structures as new nonadecapeptides were settled by detailed spectroscopic analysis and chemical degradation experiments. The chrysospermins display antibacterial and antifungal activity, and induce pigment formation by the fungus Phoma destructiva.
- Subjects :
- Antifungal Agents
Magnetic Resonance Spectroscopy
Chemical structure
Molecular Sequence Data
Peptaibol
Fungus
Microbial Sensitivity Tests
Biology
Spectrometry, Mass, Fast Atom Bombardment
High-performance liquid chromatography
chemistry.chemical_compound
Ascomycota
Drug Discovery
medicine
Amino Acid Sequence
Amino Acids
Mycelium
Peptaibols
Pharmacology
Phoma destructiva
Chromatography
Silica gel
biology.organism_classification
Anti-Bacterial Agents
medicine.drug_formulation_ingredient
chemistry
Fermentation
Peptides
Antimicrobial Cationic Peptides
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 48
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....87a33dd5283bbc187c351a237968e0eb