Carriers, channels and chloroquine efficacy in Guinea-Bissau

Authors :: Poul-Erik Kofoed
José Pedro Gil
Lars Rombo
Johan Ursing
Source :: Ursing, J, Rombo, L, Kofoed, P-E & Gil, J P 2008, ' Carriers, channels and chloroquine efficacy in Guinea-Bissau ', Trends in Parasitology, vol. 24, no. 2, pp. 49-51 . https://doi.org/10.1016/j.pt.2007.11.002
Publication Year :: 2008
Publisher :: Elsevier BV, 2008.
Abstract: Udgivelsesdato: 2008-Feb Recent studies suggest that chloroquine resistance is mediated by an energy-dependent saturable chloroquine efflux carrier. An alternative explanation is that resistance is mediated by a channel. In Guinea-Bissau high doses of chloroquine are effective, well-tolerated and commonly used. This suggests that chloroquine resistance can be overcome by higher doses. Research on the mechanism of chloroquine resistance is of utmost importance and should include the effect of higher doses.

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