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Chitosanābased delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects
- Source :
- Journal of Cellular Physiology. 234:12325-12340
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin.
- Subjects :
- 0301 basic medicine
Curcumin
Physiology
Clinical Biochemistry
Biological Availability
Pharmacology
Chitosan
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Neoplasms
Animals
Humans
Solubility
Active ingredient
Drug Carriers
Cell Biology
Bioavailability
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Pharmacokinetic aspects
Pharmacodynamics
Drug delivery
Nanoparticles
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 234
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....87a1a154b7be7526de9a238cdb2fdcdd
- Full Text :
- https://doi.org/10.1002/jcp.28024