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Chitosanā€based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects

Authors :
Mahsa Saheb
Saeideh Nemati
Thomas P. Johnston
Narges Fereydouni
George E. Barreto
Amirhossein Sahebkar
Source :
Journal of Cellular Physiology. 234:12325-12340
Publication Year :
2019
Publisher :
Wiley, 2019.

Abstract

Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water-soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan-based delivery of curcumin.

Details

ISSN :
10974652 and 00219541
Volume :
234
Database :
OpenAIRE
Journal :
Journal of Cellular Physiology
Accession number :
edsair.doi.dedup.....87a1a154b7be7526de9a238cdb2fdcdd
Full Text :
https://doi.org/10.1002/jcp.28024