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Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases
- Source :
- Van Gils, J M, Zwaginga, J J & Hordijk, P L 2009, ' Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases ', Journal of Leukocyte Biology, vol. 85, no. 2, pp. 195-204 . https://doi.org/10.1189/jlb.0708400
- Publication Year :
- 2009
-
Abstract
- Platelets, monocytes, and endothelial cells are instrumental in the development and progression of cardiovascular diseases. Inflammation, a key process underlying cardiovascular disorders, is accompanied and amplified by activation of platelets and consequent binding of such platelets to the endothelium. There, platelet-derived chemokines, in conjunction with increased expression of adhesion molecules, promote the recruitment of circulating monocytes that will eventually migrate across the endothelial lining of the vessel into the tissues. Additionally, platelets may already become activated in the circulation and may form platelet-monocyte complexes, which show increased adhesive and migratory capacities themselves but also facilitate recruitment of noncomplexed leukocytes. They should therefore be considered as important mediators of inflammation. In molecular terms, these events are additionally governed by chemokines released and presented by the endothelium as well as the different classes of endothelial adhesion molecules that regulate the interactions among the various cell types. Most important in this respect are the selectins and their ligands, such as P-selectin glycoprotein (GP) ligand 1, and the integrins binding to Ig-like cell adhesion molecules as well as to GP, such as von Willebrand factor, present in the extracellular matrix or on activated endothelium. This review aims to provide an overview of these complex interactions and of their functional implications for inflammation and development of cardiovascular disease.
- Subjects :
- Blood Platelets
Chemokine
biology
Endothelium
Cell adhesion molecule
Immunology
Integrin
Soluble cell adhesion molecules
Endothelial Cells
Inflammation
Cell Biology
Cell Communication
Monocytes
Cell biology
medicine.anatomical_structure
Cardiovascular Diseases
Cell Movement
biology.protein
medicine
Immunology and Allergy
Animals
Humans
Platelet
medicine.symptom
Selectin
Subjects
Details
- Language :
- English
- ISSN :
- 07415400
- Volume :
- 85
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of leukocyte biology
- Accession number :
- edsair.doi.dedup.....879ffb08c4879c8ab9b72a79633e900f