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Artemisia argyi attenuates airway inflammation in lipopolysaccharide induced acute lung injury model
- Source :
- Laboratory Animal Research, Vol 33, Iss 3, Pp 209-215 (2017), Laboratory Animal Research
- Publication Year :
- 2017
- Publisher :
- BMC, 2017.
-
Abstract
- Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin A (DA), on the attenuation of airway inflammation in a murine model of lipopolysaccharide (LPS)-induced acute lung injury (ALI). The C57BL/6 mice were administered AA (50 mg/kg or 100 mg/kg) and DA (10 mg/kg or 20 mg/kg) by oral gavage from day 0 to 7 days and LPS treated by intranasal instillation 48 hours before the sacrifice. The treatment of AA and DA markedly decreased inflammatory cells in the bronchoalveolar lavage fluid (BALF) compared with that in ALI-induced mice, which was accompanied by a significant reduction in the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6 in BALF. Furthermore, the administration of AA and DA clearly decreased inducible nitric oxide synthase (iNOS) expression and nuclear factor kappa B (NF-κB) phosphorylation in comparison with that in the ALI-induced mice. The histological examination of the lung tissue revealed that the administration of AA and DA suppressed the inflammatory cell infiltration into the peribronchial and alveolar lesions induced by LPS instillation. Collectively, our results indicated that AA and DA effectively decreased the airway inflammatory response induced by LPS instillation. Therefore, AA and DA may offer a potential therapy for airway inflammatory disease.
- Subjects :
- 0301 basic medicine
Artemisia argyi
Lipopolysaccharide
Inflammation
Lung injury
Pharmacology
03 medical and health sciences
chemistry.chemical_compound
medicine
lcsh:QH301-705.5
lcsh:R5-920
biology
medicine.diagnostic_test
business.industry
inducible nitric oxide synthase
Interleukin
respiratory system
dehydromatricarin A
respiratory tract diseases
Nitric oxide synthase
030104 developmental biology
Bronchoalveolar lavage
chemistry
acute lung injury
lcsh:Biology (General)
biology.protein
nuclear factor kappa B
Original Article
Tumor necrosis factor alpha
medicine.symptom
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 22337660
- Volume :
- 33
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Laboratory Animal Research
- Accession number :
- edsair.doi.dedup.....8798d0d43c7b137ddd027784d86ea308