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Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapse
- Source :
- Biological psychiatry. 61(2)
- Publication Year :
- 2006
-
Abstract
- Background: According to cognitive diathesis-stress theories, a latent cognitive vulnerability to depression is activated by negative affect in individuals at risk for depressive relapse. This vulnerability can manifest as mood-congruent memory during sad mood and may involve amygdala response, which is implicated in memory for emotionally arousing stimuli. This study examined whether amygdala modulates memory for negatively valenced words before and after a sad mood induction in healthy individuals with and without a history of recurrent major depression. Methods: Fourteen unmedicated remitted depressed (RD) and 14 matched never depressed (ND) individuals were scanned using functional magnetic resonance imaging (fMRI) while performing a self-referent encoding/evaluation task (SRET) preceding and following a sad mood challenge. After each SRET, participants’ free recall was assessed. Results: Following sad mood induction, bilateral amygdala response during encoding of valenced words predicted increased recall of negative self-referent words for a subset of RD participants. This association was not present before the sad mood induction and was not evident in individuals without a history of depression, regardless of mood state. Conclusions: These results are consistent with cognitive diathesis-stress theories and suggest a role for the amygdala in modulating mood-congruent memory during transient sad mood in individuals who are vulnerable to depression relapse.
- Subjects :
- Adult
Male
medicine.medical_specialty
Personality Inventory
Emotions
behavioral disciplines and activities
Amygdala
Recurrence
Risk Factors
mental disorders
medicine
History of depression
Image Processing, Computer-Assisted
Humans
Psychiatry
Biological Psychiatry
Cognitive vulnerability
Brain Mapping
Depressive Disorder, Major
Recall
Memoria
Cognition
Middle Aged
Verbal Learning
Image Enhancement
Magnetic Resonance Imaging
Self Concept
Oxygen
Affect
Mood
medicine.anatomical_structure
Free recall
Mental Recall
Female
Psychology
Arousal
psychological phenomena and processes
Clinical psychology
Subjects
Details
- ISSN :
- 00063223
- Volume :
- 61
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Biological psychiatry
- Accession number :
- edsair.doi.dedup.....8795d09827967ae28a7ba391d22cabcf