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Serotonin1AReceptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia
- Source :
- American Journal of Psychiatry. 161:739-742
- Publication Year :
- 2004
- Publisher :
- American Psychiatric Association Publishing, 2004.
-
Abstract
- Inhibition mediated by gamma-aminobutyric acid at the axon initial segment of pyramidal neurons appears to be altered in the prefrontal cortex in schizophrenia. This study examined the densities and laminar distribution of axon initial segments labeled with an antibody against the serotonin(1A) (5-HT(1A)) receptor, which also mediates inhibitory regulation of pyramidal neurons, in subjects with schizophrenia.The densities and laminar distribution of axon initial segments with 5-HT(1A)-like immunoreactivity were assessed in postmortem tissue from the prefrontal cortex (Brodmann's area 46) of 14 matched triads of subjects with schizophrenia, subjects with major depressive disorder, and comparison subjects with no psychiatric disorder.The relative densities of the labeled axon initial segment in both the superficial and the deep cortical layers did not differ across the three subject groups.The findings do not support a role for altered serotonin transmission by means of the 5-HT(1A) receptor in dysfunction of prefrontal cortex pyramidal neurons in schizophrenia.
- Subjects :
- Male
Depressive Disorder, Major
Psychosis
Pyramidal Cells
Central nervous system
Prefrontal Cortex
Inhibitory postsynaptic potential
medicine.disease
Axon initial segment
Axons
Psychiatry and Mental health
medicine.anatomical_structure
nervous system
Schizophrenia
Receptor, Serotonin, 5-HT1A
medicine
Humans
Major depressive disorder
Female
Serotonin
Prefrontal cortex
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 15357228 and 0002953X
- Volume :
- 161
- Database :
- OpenAIRE
- Journal :
- American Journal of Psychiatry
- Accession number :
- edsair.doi.dedup.....878625908545033fc78dc6f21e9dabb4