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Trophic factors in the pathogenesis and therapy for retinal degenerative diseases
- Source :
- Survey of Ophthalmology. 59:134-165
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Trophic factors are endogenously secreted proteins that act in an autocrine and/or paracrine fashion to affect vital cellular processes such as proliferation, differentiation, and regeneration, thereby maintaining overall cell homeostasis. In the eye, the major contributors of these molecules are the retinal pigment epithelial (RPE) and Müller cells. The primary paracrine targets of these secreted proteins include the photoreceptors and choriocapillaris. Retinal degenerative diseases such as age-related macular degeneration and retinitis pigmentosa are characterized by aberrant function and/or eventual death of RPE cells, photoreceptors, choriocapillaris, and other retinal cells. We discuss results of in vitro and in vivo animal studies in which candidate trophic factors, either singly or in combination, were used in an attempt to ameliorate photoreceptor and/or retinal degeneration. We also examine current trophic factor therapies as they relate to the treatment of retinal degenerative diseases in clinical studies.
- Subjects :
- Retinal degeneration
medicine.medical_specialty
genetic structures
Swine
Biology
Mice
Paracrine signalling
chemistry.chemical_compound
Ophthalmology
Retinitis pigmentosa
medicine
Animals
Autocrine signalling
Retinal pigment epithelium
Gene therapy of the human retina
Retinal Degeneration
Retinal
Macular degeneration
medicine.disease
eye diseases
Rats
Cell biology
Disease Models, Animal
medicine.anatomical_structure
chemistry
Intercellular Signaling Peptides and Proteins
Rabbits
sense organs
Photoreceptor Cells, Vertebrate
Signal Transduction
Subjects
Details
- ISSN :
- 00396257
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Survey of Ophthalmology
- Accession number :
- edsair.doi.dedup.....87730cd27a0fa2063d2104ff626f0d0a