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Risk of developing open-angle glaucoma in patients with carotid artery stenosis: A nationwide cohort study
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 4, p e0194533 (2018)
- Publication Year :
- 2017
-
Abstract
- Whether carotid artery stenosis (CAS) is an independent risk factor for open-angle glaucoma remains unclear. In this study, we investigated the association between CAS and the development of open-angle glaucoma in the Taiwanese population-based cohort derived from a longitudinal database containing claims data from the Taiwan National Health Insurance (NHI) program; this study enrolled 2093 patients with CAS and 8372 patients without CAS matched by age and sex from 1999 to 2010. Diagnoses of open-angle glaucoma (OAG) were identified during a follow-up period lasting through December 31, 2013. A Cox proportional hazards model was applied to evaluate the hazard ratio (HR) for OAG in the CAS cohort compared with the matched cohort. We found that the HR for open-angle glaucoma in the CAS cohort compared with the matched cohort. The adjusted HR for OAG in the CAS cohort was 1.50 (95% confidence interval, 1.11-2.02, P = .008). The Kaplan-Meier analysis revealed that the CAS cohort had a higher cumulative incidence of OAG than did the matched cohort during the follow-up period (log-rank test, P < .001). We concluded that CAS is a significantly independent risk factor for the development of OAG. Our finding is clinically important for the aging population, which has an increasing prevalence of CAS.
- Subjects :
- Male
Databases, Factual
Eye Diseases
Physiology
lcsh:Medicine
Blood Pressure
Pathology and Laboratory Medicine
Vascular Medicine
Cohort Studies
0302 clinical medicine
Endocrinology
Risk Factors
Blood Flow
Prevalence
Medicine and Health Sciences
Cumulative incidence
Carotid Stenosis
030212 general & internal medicine
lcsh:Science
Aged, 80 and over
Stenosis
education.field_of_study
Multidisciplinary
Headaches
Hazard ratio
Age Factors
Arteries
Middle Aged
humanities
Body Fluids
Carotid Arteries
Blood
Hyperlipidemia
Cohort
Hypertension
Female
Anatomy
Glaucoma, Open-Angle
Cohort study
Research Article
medicine.medical_specialty
Endocrine Disorders
Population
Taiwan
03 medical and health sciences
Sex Factors
Signs and Symptoms
Diagnostic Medicine
Internal medicine
medicine
Diabetes Mellitus
Humans
Risk factor
education
Migraine
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
Proportional hazards model
lcsh:R
Biology and Life Sciences
Retrospective cohort study
Glaucoma
eye diseases
Ophthalmology
Metabolic Disorders
030221 ophthalmology & optometry
Cardiovascular Anatomy
Blood Vessels
lcsh:Q
business
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....876e63ebb99c5237e847871f3e79e567