Additional file 3 of The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study

Additional file 3: Figure S1. Heatmap of Pearson correlation coefficients between circulating levels of amino acids in UK Biobank. Figure S2. Distribution of systolic blood pressure (SBP) and diastolic blood pressure (DBP) in 286 390 European participants without metabolomic data from UK Biobank. Figure S3. Distribution of circulating levels of amino acids in 98 317 European participants with metabolomic data from UK Biobank. Figure S4. Estimated causal effects of circulating levels of amino acids on blood pressure and risk of hypertension. Figure S5. Scatter plots of SNPs used as instrumental variables for the MR analyses of circulating amino acids with (A) systolic blood pressure, (B) diastolic blood pressure and (C)hypertension. Figure S6. Leave-one-out plots to assess if a single SNP is driving the causal effects of circulating amino acids on systolic blood pressure (SBP). Figure S7. Leave-one-out plots to assess if a single SNP is driving the causal effects of circulating amino acids on diastolic blood pressure (DBP). Figure S8. Leave-one-out plots to assess if a single SNP is driving the causal effects of circulating amino acids on hypertension. Figure S9. Scatter plots of SNPs used as IVs for the reverse MR analyses of (A) systolic blood pressure, (B) diastolic blood pressure and (C) hypertension with circulating levels of amino acids.