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Nano-antacids enhance pH neutralization beyond their bulk counterparts: synthesis and characterization
- Source :
- RSC Advances. 6:54331-54335
- Publication Year :
- 2016
- Publisher :
- Royal Society of Chemistry (RSC), 2016.
-
Abstract
- Antacids are crucial in the treatment of gastro-esophageal reflux disease and peptic ulcers. Antacids based on the calcite phase of bulk calcium carbonate have been the standard for over fifty years. More recent research has shown that nanomaterial forms of such bulk materials often have improved properties. However, the metastable vaterite form of calcium carbonate is particularly difficult to synthesize as a nanomaterial, and thus has not been extensively studied. Here, we describe the synthesis of these particles and investigate them for antacid applications. Experimental and computational approaches show that nanoscale vaterite particles maintain neutral gastric pH values three times longer than commercial antacids.
- Subjects :
- Calcite
General Chemical Engineering
medicine.medical_treatment
Inorganic chemistry
02 engineering and technology
General Chemistry
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Article
digestive system diseases
0104 chemical sciences
Nanomaterials
Characterization (materials science)
chemistry.chemical_compound
Calcium carbonate
chemistry
Antacid
Vaterite
Phase (matter)
Nano
medicine
0210 nano-technology
Subjects
Details
- ISSN :
- 20462069
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- RSC Advances
- Accession number :
- edsair.doi.dedup.....874eb05d60763d43b3c20c465b9c1e8f