5,5-Dimethyl-2,2-di(pyridin-2-yl)hexahydropyrimidine

Novel 5,5-dimethyl-2,2-di(pyridin-2-yl)hexahydropyrimidine was synthesized in good yield by a one-pot condensation reaction of 2,2-dimethylpropane-1,3-diamine with di(pyridin-2-yl)methanoneusing dichloromethane as solvent at room temperature. The structure of the synthesized compound was assigned on the basis of its elemental analysis, UV-visible, 1 H-NMR, 13 C-NMR, IR, and mass spectral data. Keywords: hexahydropyrimidine; 2,2-dimethylpropane-1,3-diamine; di(pyridin-2-yl)methanone Introduction The six-membered heterocyclic hexahydropyrimidine unit is present in several natural products and pharmaceutical agents of various pharmacological activities [1]. Hexahydropyrimidines are also found in many bioactive compounds, like antiinflammatory and analgesic agents, fungicides, antibacterials, parasiticides, and antivirals [2]. They also behave as prodrugs of pharmacologically active di- and polyamines [3,4]. Several derivatives of hexahydropyrimidines are used as polymers stabilizers [5]. Due to their facile cleavage under mild acidic conditions, hexahydopyrimidines have been employed in organic synthesis as protective groups in the selective acylation by addition of 1,3-diamines [6]. Furthermore, hexahydropyrimidines and some of their derivatives form good polydentate nitrogen donor complexes, they coordinate the transition metal ions in mono-, di-, or poly-coordination mode [7–9].