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Satisfaction with the Use of eFlow Closed-System Nebulizer in Patients with Moderate-to-Very Severe Chronic Obstructive Pulmonary Disease: Findings from a Long-Term Safety Study
- Source :
- Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32:24-33
- Publication Year :
- 2019
- Publisher :
- Mary Ann Liebert Inc, 2019.
-
Abstract
- Effective delivery of inhaled drugs in chronic obstructive pulmonary disease (COPD) depends on patients' ability to correctly use an inhalation device. Nebulized delivery may be appropriate for COPD patients who cannot coordinate breath with inhalation or generate adequate inhalational force. Until recently, long-acting muscarinic antagonists (LAMAs), used for maintenance treatment of COPD, were available for delivery only via handheld inhalers. Lonhala™ Magnair™ (glycopyrrolate inhalation solution) is a LAMA delivered via the eFlowGOLDEN-5, a phase 3, randomized, open-label trial, evaluated the safety and efficacy of glycopyrrolate/eFlow CS 50 μg twice daily versus tiotropium 18 μg once daily (administered via HandiHaler™) in patients with moderate-to-very severe COPD. Only patients in the glycopyrrolate/eFlow CS group completed a study-specific device use questionnaire, evaluating patients' perceptions about ease of use, confidence in drug delivery, and overall device satisfaction at week 48 or end of study. Responses were summarized by counts and percentages.Of 620 patients who received glycopyrrolate/eFlow CS, 454 completed the questionnaire (mean age [standard deviation, SD] 63.3 [8.5] years; mean BMI [SD] 28.45 [6.208] kg/mHigh levels of satisfaction, confidence, and ease of use were reported with the eFlow CS nebulizer in this study. These findings support the use of the eFlow CS for maintenance treatment of COPD with glycopyrrolate inhalation solution.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Pharmaceutical Science
Pulmonary disease
Muscarinic Antagonists
Severity of Illness Index
030226 pharmacology & pharmacy
Severe chronic obstructive pulmonary disease
Pulmonary Disease, Chronic Obstructive
03 medical and health sciences
0302 clinical medicine
Administration, Inhalation
Humans
Medicine
Pharmacology (medical)
In patient
Tiotropium Bromide
Intensive care medicine
Lung
Glycopyrrolate
Aged
COPD
Inhalation
business.industry
Nebulizers and Vaporizers
Equipment Design
Middle Aged
medicine.disease
Bronchodilator Agents
Nebulizer
Treatment Outcome
030228 respiratory system
Patient Satisfaction
Female
Long term safety
business
Subjects
Details
- ISSN :
- 19412703 and 19412711
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Aerosol Medicine and Pulmonary Drug Delivery
- Accession number :
- edsair.doi.dedup.....872a38f6e025921d8871e8a8d95fc6fd